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Living with macular telangiectasia type 2

Update on Idiopathic Macular Telangiectasia Type

  1. The macular area shows typical features of macular telangiectasia type 2, including opacification of the retina, presence of retinal pigment epithelial hyperpigmentation, and presence of crystalline deposits. Figure 2
  2. Macular telangiectasia type 2 is a bilateral disease of unknown cause with characteristic alterations of the macular capillary network and neurosensory atrophy. Its prevalence may be underestimated and has recently been shown to be as high as 0.1% in persons 40 years and older
  3. Idiopathic Juxtafoveal Telangiectasia Type II (Macular Telangiectasia type 2) John J Chen, MD, PhD; Angela R McAllister, MD; Elliott H Sohn, MD. February 17, 2014. Chief complaint: Decreased vision and a central scotoma in both eyes (OU). History of Present Illness: The patient is a 43-year-old male who presented with decreased vision and a central scotoma OU for the past 10 years, which has.
  4. e the genetic penetrance of MacTel. Design, setting, and participants: Descriptive cross-sectional study of patients with MacTel at a tertiary referral eye center

Macular telangiectasia type 2 - ncbi

Macular Telangiectasia Type 2 is a rare bilateral neurodegenerative disorder of the macula in the eye. It causes the blood vessels in the center of the macula to dilate and leak, which can cause central vision loss. Macular edema or thickening of the macula may also occur. Common symptoms reported by people with macular telangiectasis type 2 September 21, 2017 Macular telangiectasia (MacTel) type 2 is a slowly progressive, bilateral disorder of the pericentral maculae characterized by vascular and neuroglial retinal degeneration. Symptoms often start around the fifth decade of life and frequently include difficulty with reading due to missin Macular telangiectasia type 2 is a rare disease of the retina that leads to a gradual loss of central vision. MacTel is estimated to affect about 0.1% of the population, and its onset is age-related. Affected individuals are typically diagnosed in their 40s and 50s

Idiopathic Juxtafoveal Telangiectasia Type II (Macular

Type 2 affects both eyes but not always with the same severity. Type 1 MacTel In Type 1 MacTel, the blood vessels dilate and tiny aneurysms form, which leak and cause swelling. This is called macular edema and it damages macular cells Type 2 macular telangiectasia, sometimes abbreviated as MacTel, is much more common. With Type 2, the blood vessels in the macula become dilated and leak fluid, causing swelling and scarring, which can lead to vision loss. 3  Sometimes new blood vessels grow beneath the macula, affecting the macular photoreceptors and causing loss of vision

Genetic Penetrance of Macular Telangiectasia Type

Group 2 patients are characterized by retinal juxtafoveolar telangiectasia, minimal exudation, superficial retinal crystalline deposits, and right-angle venules (small veins, especially one joining capillaries to larger veins) According to the Mac Tel Project, 50% of type 2 patients with have a visual acuity of 20/32 or better, with a mean visual acuity of 20/40. Mac Tel can rarely lead to 20/200 or worse vision when associated with full-thickness macular hole or subretinal neaovascularization that can lead to a disciform scar in very advanced stages

Macular telangiectasis type 2 symptoms, treatments

  1. Macular telangiectasia (MacTel) type 2 is a bilateral macular disease that is characterised by both neurodegenerative and vascular alterations, and a slowly progressive disease course. 1 Structural and functional alterations are usually limited to an oval-shaped area centred on the fovea, of approximately 8° horizontal and 5° vertical diameter
  2. Mission Statement: The Lowy Medical Research Institute is dedicated to preventing vision loss in people with macular telangiectasia type 2 (MacTel). LMRI investigators work collaboratively to study possible causes of MacTel, to develop new therapies, and to bring those therapies to patients
  3. Scientists have discovered the first evidence of genes that cause Macular Telangiectasia type 2 (MacTel), a degenerative eye disease which leads to blindness and is currently incurable and..
  4. Idiopathic Juxtafoveal Telangiectasis. (pronounced tell an gee ACT te sis) (JFT), also known as perifoveal telangiectasis or mac-tel for macular telangiectasia, is a condition in which abnormalities develop in blood vessels at the center of the retina. This central part of the retina, called the fovea, is responsible for the sharp vision needed.
  5. Macular telangiectasia type 2 (Mac Tel 2) also known as idiopathic perifoveal telangiectasia and juxtafoveolar retinal telangiectasis type 2A is an enigmatic disease of unknown etiology. It manifests both neurodegenerative and vasculopathic characteristics. It manifests itself during the fifth or sixth decades of life
  6. Macular telangiectasia type 2 (MacTel) is a bilateral disease with characteristic alterations of the macular capillary network and neural atrophy. 1 Its prevalence has been shown to be as high as 0.1% in persons aged 43 to 86 years in the Beaver Dam Eye Study based on grading from stereoscopic fundus photographs. 2 Vascular and neurodegenerative hypotheses have been proposed to explain the.
Murray KILLINGSWORTH | Clinical scientist | PhD

Type 2 macular telangiectasia is typically diagnosed in people aged in their 40s and 50s. People with macular telangiectasia tend to have a higher prevalence of diabetes and high blood pressure MacTel (macular telangiectasia type 2) affects one in 1,000 Australians. Symptoms include slow loss of vision, distorted vision and trouble reading. Because early signs of the disorder are subtle,..

Gaining New Insights Into MacTel - retina-specialist

Macular telangiectasia type 2 (MacTel) was originally described by several researchers as an idiopathic juxtafoveal retinal telangiectasis. 1-3 MacTel is characterized by pigment clumping and telangiectatic vessels temporal to the macula, commonly with outer and inner temporal juxtafoveal cavitations and thinning En face optical coherence tomography (OCT) can be used to quantify areas of hyperreflective lesions in macular telangiectasia type 2 (MacTel), according to research results published in Investigative Ophthalmology & Visual Science.These lesions are associated with an almost complete loss of retinal sensitivity, the research says. In a retrospective, cross-sectional, cohort study, researchers. Internal limiting membrane (ILM) drape sign is an important OCT characteristic of Macular telangiectasia type 2 (MacTel 2). Described here is a case where masking of the ILM drape sign occurred with bilateral foveal detachments in a patient with MacTel 2 Macular telangiectasia type 2 (MacTel Type 2) is an uncommon eye disorder that results in slow vision loss beginning in middle age. The macula is the central part of the retina, which lines the back of the eye like the film of a camera. The macula is responsible for central or reading vision Macular telangiectasia type 2 Synonyms: Idiopathic juxtafoveal retinal telangiectasis, Idiopathic juxtafoveal telangiectasis, IJT, Idiopathic macular telangiectasia, Perifoveal telangiectasis, Type 2 MacTel, Idiopathic MacTel, IJFT, Juxtafoveal retinal telangiectasia type 2, Idiopathic juxtafoveal retinal telangiectasia

The purpose of this study is to develop a Registry of participants with MacTel Type 2 (as confirmed by the Reading Center) who may agree to be contacted for inclusion in future clinical trials. The Registry participants include new participants and participants from the NHO, Genetic I and Genetics II studies who agree to continue to participate A Phase III Multicenter Randomized, Sham Controlled, Study to Determine the Safety and Efficacy of NT-501 in Macular Telangiectasia Type 2. This study is a phase 3, randomized, multi-center study to evaluate the efficacy and safety of the NT-501 implants in participants with macular telangiectasia type 2. Baseline through 24 months

Diagnosing MacTel - The Lowy Medical Research Institut

Charbel Issa P, Gillies MC, Chew EY, et al. Macular telangiectasia type 2. Progress in Retinal and Eye Research 2013;34:49-77. 7. Chew EY, Clemons TE, Peto T, et al. Ciliary neurotrophic factor for macular telangiectasia type 2: results from a phase 1 safety trial. American Journal of Ophthalmology 2015;159:659-666. 8 Open. A Natural History Observation and Registry Study of Macular Telangiectasia Type 2: The MacTel Study Rochester, Minn. . The purpose of this study is to develop a Registry of participants with MacTel Type 2 (as confirmed by the Reading Center) who may agree to be contacted for inclusion in future clinical trials

What Is Macular Telangiectasia? - American Academy of

Macular Telangiectasia: Types, Symptoms, Diagnosis, Treatmen

  1. Macular telangiectasia type 2 (Mac Tel 2) also known as idiopathic perifoveal telangiectasia and juxta-foveolar retinal telangiectasis type 2A is an enigmatic disease of unknown etiology. It manifests both neurodegenerative and vasculopathic characteristics. It manifests itself during the fifth or sixth decades of life
  2. Scientists at the Lowy Medical Research Institute (LMRI) have discovered one cause of a progressive, debilitating eye disease called macular telangiectasia type 2 (MacTel). The work, using genetic.
  3. Macular Telangiectasia Type 2. Patients with MT2 have abnormal parafoveal retinal capillaries most concentrated temporally. While these capillary abnormalities have given rise to the condition's name, at its core MT2 is best described as a neurovascular macular degenerative condition
  4. In retinal angiomatous proliferation and macular telangiectasia type 2, PR-OCTA can trace the pathologic vascular extension into deeper layers as the disease progress through stages. Plexus-specific visualization and measurement of retinal vascular changes are improving our ability to diagnose, stage, monitor, and assess treatment response in a.

Retinal Telangiectasias - Living Well With Low Visio

Although macular telangiectasia type 2 was initially described as a primarily vascular condition, new insights into the pathogenesis has shifted the definition toward neurodegeneration with depletion of Müller cells forming a key component. 1,2 The disease may be considered in two forms: a non-proliferative and proliferative stage Zhang Q, Wang R, Chen C, et al. Swept source optical coherence tomography angiography of neovascular macular telangiectasia type 2. Retina. 2015;35(11):2285-2299. Spaide RF, Klancnik JM, Cooney MJ. Retinal vascular layers in macular telangiectasia type 2 imaged by optical coherence tomographic angiography. JAMA Ophthalmol. 2015;133(1):66-73 A recent study using AOSLO in Type 2 macular telangiectasia reported that areas of dark cones might recover over time.32 Dark cones may indicate potential target areas for localized treatments such as gene therapy. Future Directions AOSLO technology provides us with an unprecedented view of the retina at a cellular level The objective of this research study is to better understand macular telangiectasia Type 2 (MacTel Type 2), an uncommon eye disorder that results in slow vision loss beginning in middle age. The macula is the central part of the retina responsible for central or reading vision. Telangiectasis refers to dilated, leaky blood vessels Idiopathic Macular Telangiectasia (MacTel) is a vascular anomaly affecting retinal capillaries in the juxtafoveal region. 1 The aetiology and pathogenesis of the disease are little known. According to a system originally devised by Gass and Blodi 2 and subsequently simplified by Yanuzzi et al. 3, MacTel is classified into two main categories, based on biomicroscopic and fluorescein.

MacTel 2 is an acquired neurodegenerative and vasculopathic macular disorder [].Yanuzzi et al. proposed two distinct types: Type 1 or aneurysmal telangiectasia and the more common Type 2 perifoveal telangiectasia, which can be further classified into a non-proliferative and a proliferative stage [].It is well recognised that OCT has allowed the detection of a wide range of foveal signs in. in macular telangiectasia type 2 Anmar Abdul-Rahman Abstract Background: Internal limiting membrane (ILM) drape sign is an important OCT characteristic of Macular telangiectasia type 2 (MacTel 2). Described here is a case where masking of the ILM drape sign occurred with bilateral foveal detachments in a patient with MacTel 2 To characterize the phenotype and investigate the associations of intraretinal crystalline deposits in a large cohort with type 2 idiopathic macular telangiectasia (MacTel).Case-control study.Patients with and without retinal crystals from the Macular Telangiectasia Project, an international multicenter prospective study of type 2 MacTel.Grading of stereoscopic 30-degree color fundus (CF. MacTel type 2 is also characterized by loss of macular transparency, superficial white crystals, depletion of macular pigment and progressive foveal thinning. 1 - 5 More advanced cases may develop pigment clumping and less commonly, subretinal neovascularization leading to severe visual loss. 2 The cause of MacTel type 2 is not known, and no. MacTel type 2 is also characterized by loss of macular transparency, superficial white crystals, depletion of macular pigment and progressive foveal thinning.1-5 More advanced cases may develop pigment clumping and less commonly, subretinal neovascularization leading to severe visual loss.2 The cause NIH-PA Author Manuscript of MacTel type 2.

Macular telangiectasia type 2 also known as idiopathic perifoveal telangiectasia and juxtafoveolar retinal telangiectasis type 2A is an acquired bilateral neurodegenerative macular disease that manifests itself during the fifth or sixth decades of life Macular telangiectasia Type 2 (MacTel) is an uncommon eye disease causing central vision loss.Clinical manifestations of the disease include macular pigment loss, vascular changes, cavitations in the inner and outer retina, and perifoveal photoreceptor degeneration. 1 Some of the earliest signs of the disease are loss of retinal transparency 2 and loss of macular pigment in a sharply. 9. Spaide RF, Klancnik JM, Cooney MJ. Retinal vascular layers in macular telangiectasia type 2 imaged by optical coherence tomographic angiography. JAMA Ophthalmol. 2015;133(1):66-73. 10. Thorell MR, Zhang Q, Huang Y, et al. Swept-source OCT angiography of macular telangiectasia type 2. Ophthalmic Surg Lasers Imaging Retina. 2014; 45:369-380 Idiopathic Juxtafoveal Macular Telangiectasia (MacTel) is a blinding condition of the retina about which little is known. The purpose of The MacTel Project is to identify the causes and most appropriate treatments for the condition. The research is conducted for and funded by the Lowy Medical Research Institute, Ltd Macular Telangiectasia Type 2 In macular telangiectasia type 2, OCTA demonstrates reduced capillary density and the deep inner retinal plexus is more prominently involved. 53,54 Telangiectasias, increased intercapillary area, vascular dilation or rarefication, capillary anastomoses between the superficial and deep inner retinal plexuses, and.

Macular Telangiectasia - EyeWik

Genetic Penetrance of Macular Telangiectasia Type 2. Cecinio C. Ronquillo, Kimberley Wegner, Charles M. Calvo, Paul S. Bernstein The utility of ultra-widefield fluorescein angiography in pediatric. Renewed attention is being directed to luteal pigment loss in the perplexing neurodegenerative disease, idiopathic macular telangiectasia type 2 (IMT2 or MacTel). In the first controlled study of off-label Age-Related Eye Disease Study 2 (AREDS2) oral supplement, patients with MacTel maintained more stability in visual acuity and anatomic. We are open for safe in-person care. Learn more: Mayo Clinic facts about coronavirus disease 2019 (COVID-19) Our COVID-19 patient and visitor guidelines, plus trusted health information Latest on COVID-19 vaccination by site: Arizona patient vaccination updates Arizona, Florida patient vaccination updates Florida, Rochester patient vaccination updates Rochester and Mayo Clinic Health System. Feb 3, 2018 - Explore Cheryl Shuber's board Mactel Eye Disease on Pinterest. See more ideas about eye diseases, disease, low vision

Genome Medicine volume 13, Article number: 39 (2021) Cite this article. Macular telangiectasia type 2 (MacTel) is a rare, heritable and largely untreatable retinal disorder, often comorbid with diabetes. Genetic risk loci subtend retinal vascular calibre and glycine/serine/threonine metabolism genes. Serine deficiency may contribute to MacTel via neurotoxic deoxysphingolipid production. Objective Idiopathic macular telangiectasia (MacTel) is considered primarily a vascular disease affecting juxtafoveal retinal capillaries. However, recent evidence suggests that neuronal changes may occur early in disease development. We used high-resolution adaptive optics retinal imaging to elucidate the foveal cone photoreceptor changes at a cellular level in patients with MacTel The Role of Macular Pigment Carotenoids in the Pathogenesis and Treatment of Macular Telangiectasia Type 2 (MacTel) Latest version (submitted June 21, 2017) on ClinicalTrials.gov. A study version is represented by a row in the table. Select two study versions to compare. One each from columns A and B

Right-angled vessels in macular telangiectasia type 2

  1. This is a two armed Single Masked Pilot Study enrolling participants with Macular Telangiectasia Type 2 who will be randomized to undergo either a subthreshold photothermal treatment or a sham procedure to one eye. The participants will be followed for one year with visits at 1 month, 3 months, 6 months and 12 months post-treatment (laser or sham)
  2. Retinal Crystals in Type 2 Idiopathic Macular Telangiectasia Sallo FB, Leung I, Chung M, Wolf-Schnurrbusch UEK, Dubra A, Williams DR, Clemons T, Pauleikhoff D, Bird AC, Peto T, MacTel Study Group.
  3. The Macular Telangiectasia Project found a prevalence of diabetes mellitus of 28% and hypertension of 52% in macular telangiectasia type 2. Such high prevalence of diabetes mellitus, high blood pressure and the age of onset of the disease can point toward a long-term vascular stress as the etiology for this entity
  4. Cellular Functional Architecture of the Human Cone Photoreceptor Mosaic By William Scott Tuten A dissertation submitted in partial satisfaction of th
  5. Macular Telangiectasia type 2 (Mac Tel 2) is a rare retinal neurodegenerative condition that leads to late-onset progressive central vision loss 47,48. Early clinical findings, including retinal.
  6. Macular telangiectasia type 2 (Disease) interactions between genes and environment may also play a role inn the development of MacTel type 2.[5] Some researchers have speculated that people with diabetes, hypertension, obesity, or other health, experience with this disease
  7. Macular pigment is a yellowish pigment of purely dietary origin, which is thought to have a protective role in the retina. Recently, it was linked to age-related macular degeneration and improved visual function. In this work, we present a method and a corresponding optical instrument for the rapid measurement of its optical density. The method is based on fundus reflectometry and features a.

Video: Macular telangiectasia type 2 - ScienceDirec

The Lowy Medical Research Institut

OCTA is a good method for imaging the microvasculature in the diseases that affect the central macula, including age-related macular degeneration (AMD), diabetic maculopathy, retinal vascular occlusion, macular telangiectasia type 2 and the microvasculature in optic nerve diseases. 4-11 Additionally, using OCTA, features of some disorders. Since the publication of the Age-Related Eye Disease Study 2 (AREDS2) in 2013, the macular pigment carotenoids lutein (L) and zeaxanthin (Z) have become well known to both the eye care community and the public. It is a fascinating aspect of evolution that primates have repurposed photoprotective pigments and binding proteins from plants and insects to protect and enhance visual acuity Jacque Duncan, MD. Retinitis pigmentosa (RP) affects about 1 in 3,500 people worldwide. Age-related macular degeneration (AMD) affects as many as 1 in 4 people by the age of 75 and is the leading cause of blindness in people over age 50 in the United States. Both RP and AMD have a hereditary basis, and currently, there is no cure for either of.

World-first genetic clues point to risk of blindness

Purpose To evaluate the utility of optical coherence tomography-angiography (OCT-A) for monitoring activity, progression and response to therapy of neovascularisations (NVs) secondary to macular telangiectasia type 2 (MacTel). Methods In a retrospective analysis, eyes with NVs secondary to MacTel were reviewed over a period of ≥8 months 6. Zhang, Q, Chen, C-L, Chu, Z, Wang, RK. Wide Field OCT Angiography by Using Swept-Source OCT in Living Human Eye. Ophthalmic Technologies between Proliferative Macular Telangiectasia Type 2 and Neovascular Age-Related Macular Degeneration. Zheng, F, Shi, Y, Gregori, G, Rosenfeld, PJ. Anatomic Localization of Type 1 and Type 2 Macular. For instance, the ⁠ Carrier Screening for Rare Diseases is a great app for genetic testing for disease. It can identify the following genetic diseases: 17 Alpha-hydroxylase / 17,20-Lyase Deficiency, Combined Complete. 17 Beta-hydroxysteroid Dehydrogenase 3 Deficiency. 25-hydroxyvitamin D Deficiency The patients were divided into two groups according to the following categories: 1) regression of prechoroidal cleft: regression group vs. non-regression group and 2) type of neovascularization: neovascular AMD group vs. PCV group. Changes in visual acuity during the follow-up period were also compared between the two groups

European Medicines Agency - For help on how to get the results you want, see our search tips Multifocal ERG Defects Associated with Insufficient Long-Term Glycemic Control in Adolescents with Type 1 Diabetes Multifocal Extensive Spinal Tuberculosis with Retropharyngeal Abscess Multifocal electroretinography in type 2 idiopathic macular telangiectasia Abstract. Introduction: Macular telangiectasia type 2 has also been termed idiopathic perifoveal telangiectasia or idiopathic juxtafovealtel angiectasis type 2 [1-4]. It is now referred to as MacTel type 2, and it is a bilateral perifoveal vasculopathy which originates in the deep retinal capillary plexus in the temporal juxtafoveal region Macular telangiectasia type 2 is an acquired idiopathic retinal disorder characterized by dilation and ectasia of perifoveal capillaries which may be complicated by neovascularization. OCT-A shows reduced capillary density in both superficial and deep layers in the foveal zone Macular Dystrophy - most often used to refer to a juvenile form of MD Cone-Rod Dystrophy Sorsby's Macular Dystrophy. Macular telangiectasia abbreviated MacTel, sometimes referred to as idiopathic juxtafoveal macular telangiectasia. There's Type 1 and Type 2. What these types of macular degeneration have in common: CNV (Choroidal.

Four cases were similar to the clinical picture of type 2 macular telangiectasia (Mac Tel type 2), two of which presenting macular capillary telangiectasias and crystalline deposits, one other revealing extensive macular atrophy, intraretinal cysts, and crystal deposits, and the fourth one showing macular graying and both crystalline and. Age-related macular degeneration (AMD) is the most common cause of visual loss in the developed world with ~196 million people worldwide living with AMD, which is predicted to rise to 288 million by 2040 (Wong et al., 2014). Pathology associated with AMD occurs in the retina, a photosensitive membrane in the posterior segment of the eye which. (Six patients with systemic mastocytosis were treated with 0.5 to 3.0 mu/d of interferon-alpha (IFN-alpha). Resolution of ascites was seen in 2/2 patients and a decrease in adenopathy was observed in 2/4 patients. There was a 5-10% decrease in bone marrow mast cells in 5/6 patients after 9-12 months of therapy

Other disorders that might be confused with Coats disease include familial exudative vitreoretinopathy (FEVR) and macular telangiectasia, type I. Diagnosis. A diagnosis of Coats disease is made based upon a thorough clinical ophthalmic evaluation, a detailed patient history, and specialized tests, including retinal fluorescein angiography. Spinocerebellar ataxia (SCA) is a progressive, degenerative, genetic disease with multiple types, each of which could be considered a neurological condition in its own right. An estimated 150,000 people in the United States have a diagnosis of spinocerebellar ataxia at any given time.SCA is hereditary, progressive, degenerative, and often fatal The assessment of the EZ has been utilized to evaluate photoreceptor structure in several macular disorders, including macular hole, macular telangiectasia type 2 and age-related macular degeneration [12,13,14]. The purpose of this study was to evaluate the association of levels of ionic calcium and HbA1c with photoreceptor EZ disruption in DR

To evaluate visual function and disease progression in the retinal structural abnormalities of three patients from two unrelated families with macular telangiectasia (MacTel) type 2. Adaptive optics scanning laser ophthalmoscopy (AOSLO) and AOSLO microperimetry (AOMP) were used to evaluate the structure and function of macular cones in three. 1. Powner MB, Gillies MC, Zhu M, Vevis K, Hunyor AP, Fruttiger M. Loss of Muller's cells and photoreceptors in macular telangiectasia type 2. Ophthalmology. 2013;120(11):2344-5

This study might also add a new piece to the puzzle of the pathogenesis of macular telangiectasia type 2 which is characterized by a loss of Müller cells and a reduction of SCE (Powner et al., 2013; Zhao et al., 2015). Conclusions. This paper shows the 3D anatomy of primate foveolar Müller cells and cones for the first time Macular telangiectasia is a disorder of retinal cells and tiny blood vessels located in the center of the retina. It has also been called juxtafoveal telangiectasis. The retina in your eye is like the film inside a camera. The retina takes the picture of objects you look at and sends the message to the brain

Living reference work entry. First Online: 17 July 2021. Confocal blue reflectance imaging in type 2 idiopathic macular telangiectasia. Investig Ophthalmol Vis Sci. 2008;49(3):1172-7. CrossRef Google Scholar. 28. Charbel Issa P, Gillies MC, Chew EY, Bird AC, Heeren TFC, Peto T, et al. Macular telangiectasia type 2. Prog Retin Eye Res. Toto, L, Di Antonio, L, Mastropasqua, R. Multimodal imaging of macular telangiectasia type 2: focus on vascular changes using optical coherence tomography angiography. Invest Ophthalmol Vis Sci 2016; 57: 268 - 276. Google Scholar | Crossre

Overview. Michael Powner is a Senior lecturer in Neurobiology, joining the Optometry division at City, University of London in February 2016. Michael gained his BSc in Molecular Biology and Biochemistry from Durham University in 2006. Followed by a PhD in Neurobiology from University College London in 2011 Macular telangiectasia (MacTel) type 2 or juxtafoveal retinal telangiectasia is a bilateral disease of unknown cause with characteristic biomicroscopic and angiographic characteristics. Advances in imaging techniques, particularly using FAF imaging and SD-OCT, have led to remarkable progress in the understanding of MacTel ( Figure 10 ) Macular degeneration is a disease characterized by a malfunction of cells that are responsible for sensing light within the eye. Macular degeneration is the most common cause of central vision loss in individuals older than 50 years old. In fact, macular degeneration is usually referred to as age-related macular degeneration (AMD)

Fluorescence lifetime imaging ophthalmoscopy (FLIO) has developed as a new diagnostic tool in ophthalmology. FLIO measurements are taken from 30° retinal fields in two spectral channels (short spectral channel (SSC): 498-560 nm, long spectral channel (LSC): 560-720 nm). Because of the layered structure of the eye, the detected signal is an interaction of the fluorescence decay of the. AFI, Autofluorescence imaging; AMD, Age-related macular degeneration; AREDS, Age-Related Eye Disease Study; AREDS2, Age-Related Eye Disease Study 2; BCO1, b-carotene oxygenase 1 (also known as b -carotene-15 0 ,15 0 -monoxygenase); BCO2, -carotene oxygenase 2 (also known as b , b -carotene-9 ,10 -dioxygenase); cHFP, Customized hetero Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression MacTel Consortium, 09 Mar 2021, In: genome medicine. 13, 11 p., 39. Research output: Contribution to journal › Article › peer-revie

Macular degeneration causes vision loss and primarily affects people age 65 and older. The condition affects the macula, the sensitive part of the retina responsible for sharp, central vision. There are two major types of age-related macular degeneration, dry and wet. The dry type is more common, accounting for about 90% of cases This review includes a detailed description of FLIO findings in the healthy eye, as well as age-related macular degeneration (AMD), diabetic retinopathy (DR), macular telangiectasia type 2 (MacTel), albinism, retinal vessel occlusion, Stargardt disease, central serous chorioretinopathy (CSCR), choroideremia, retinitis pigmentosa (RP), and. J. Loo, C.X. Cai, J. Choong, E. Chew, M. Friedlander, G.J. Jaffe, and S. Farsiu, Deep learning-based classification and segmentation of retinal cavitations on optical coherence 2 tomography images of macular telangiectasia type 2, British Journal of Ophthalmology, (IN PRESS) 202